Cargando…

Metabolic Profiling of Adiponectin Levels in Adults: Mendelian Randomization Analysis

BACKGROUND—: Adiponectin, a circulating adipocyte-derived protein, has insulin-sensitizing, anti-inflammatory, antiatherogenic, and cardiomyocyte-protective properties in animal models. However, the systemic effects of adiponectin in humans are unknown. Our aims were to define the metabolic profile...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borges, Maria Carolina, Barros, Aluísio J.D., Ferreira, Diana L. Santos, Casas, Juan Pablo, Horta, Bernardo Lessa, Kivimaki, Mika, Kumari, Meena, Menon, Usha, Gaunt, Tom R., Ben-Shlomo, Yoav, Freitas, Deise F., Oliveira, Isabel O., Gentry-Maharaj, Aleksandra, Fourkala, Evangelia, Lawlor, Debbie A., Hingorani, Aroon D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736126/ https://www.ncbi.nlm.nih.gov/pubmed/29237687 http://dx.doi.org/10.1161/CIRCGENETICS.117.001837

Ejemplares similares

Role of Adiponectin in Coronary Heart Disease Risk: A Mendelian Randomization Study
por: Borges, Maria Carolina, et al.
Publicado: (2016)

Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants
por: Borges, Maria Carolina, et al.
Publicado: (2020)

Mendelian Randomisation study of the influence of eGFR on coronary heart disease
por: Charoen, Pimphen, et al.
Publicado: (2016)

Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance
por: Sae-jie, Wichanon, et al.
Publicado: (2023)

Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset
por: Blyuss, Oleg, et al.
Publicado: (2015)

Inflammation, Insulin Resistance, and Diabetes—Mendelian Randomization Using CRP Haplotypes Points Upstream
por: Brunner, Eric J, et al.
Publicado: (2008)

Association of skirt size and postmenopausal breast cancer risk in older women: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
por: Fourkala, Evangelia-Ourania, et al.
Publicado: (2014)

Socioeconomic indicators of health inequalities and female mortality: a nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
por: Bailey, Katharine, et al.
Publicado: (2015)

Colorectal cancer ascertainment through cancer registries, hospital episode statistics, and self-reporting compared to confirmation by clinician: A cohort study nested within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
por: Thomas, Darren S., et al.
Publicado: (2019)

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
por: Swerdlow, Daniel I, et al.
Publicado: (2016)

Association of serum sex steroid receptor bioactivity and sex steroid hormones with breast cancer risk in postmenopausal women
por: Fourkala, Evangelia-Ourania, et al.
Publicado: (2012)

A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival
por: Anjum, Shahzia, et al.
Publicado: (2014)

Alcohol consumption and cognitive performance: a Mendelian randomization study
por: Kumari, Meena, et al.
Publicado: (2014)

Cancer-associated autoantibodies to MUC1 and MUC4—A blinded case–control study of colorectal cancer in UK collaborative trial of ovarian cancer screening
por: Pedersen, Johannes W, et al.
Publicado: (2014)

Ovarian cancer screening—Current status, future directions()
por: Menon, Usha, et al.
Publicado: (2014)

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
por: White, Jon, et al.
Publicado: (2016)

Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults
por: Joshi, Roshni, et al.
Publicado: (2020)

Evaluation of Genetic Markers as Instruments for Mendelian Randomization Studies on Vitamin D
por: Berry, Diane J., et al.
Publicado: (2012)

Lipid lowering and Alzheimer disease risk: A mendelian randomization study
por: Williams, Dylan M., et al.
Publicado: (2019)

The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study
por: Borges, Maria-Carolina, et al.
Publicado: (2022)

Commentary: Two-sample Mendelian randomization: opportunities and challenges
por: Lawlor, Debbie A
Publicado: (2016)

Histological confirmation of breast cancer registration and self-reporting in England and Wales: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening
por: Fourkala, E O, et al.
Publicado: (2012)

Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases
por: Lindbohm, Joni V., et al.
Publicado: (2022)

NMR metabolomic modelling of age and lifespan: a multi-cohort analysis
por: Lau, Chung-Ho E., et al.
Publicado: (2023)

Concordance of National Cancer Registration with self-reported breast, bowel and lung cancer in England and Wales: a prospective cohort study within the UK Collaborative Trial of Ovarian Cancer Screening
por: Gentry-Maharaj, A, et al.
Publicado: (2013)

Establishing reference intervals for triglyceride-containing lipoprotein subfraction metabolites measured using nuclear magnetic resonance spectroscopy in a UK population
por: Joshi, Roshni, et al.
Publicado: (2020)

Discovery of serum biomarkers of ovarian cancer using complementary proteomic profiling strategies
por: Timms, John F., et al.
Publicado: (2014)

Novel risk models for early detection and screening of ovarian cancer
por: Russell, Matthew R., et al.
Publicado: (2016)

Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples
por: Thomas, D S, et al.
Publicado: (2015)

Does High C-reactive Protein Concentration Increase Atherosclerosis? The Whitehall II Study
por: Kivimäki, Mika, et al.
Publicado: (2008)

Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children
por: Bonilla, Carolina, et al.
Publicado: (2012)

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
por: Borges, Maria Carolina, et al.
Publicado: (2022)

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene
por: Fairoozy, Roaa Hani, et al.
Publicado: (2017)

Mendelian randomization of blood lipids for coronary heart disease
por: Holmes, Michael V., et al.
Publicado: (2015)

Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study
por: Hartwig, Fernando Pires, et al.
Publicado: (2017)

Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome
por: Storm, Catherine S., et al.
Publicado: (2021)

Genetic drug target validation using Mendelian randomisation
por: Schmidt, Amand F., et al.
Publicado: (2020)

Early detection of cancer in the general population: a blinded case–control study of p53 autoantibodies in colorectal cancer
por: Pedersen, J W, et al.
Publicado: (2013)

Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration: A Mendelian Randomization Study
por: Kuan, Valerie, et al.
Publicado: (2021)

Protein Z: A putative novel biomarker for early detection of ovarian cancer
por: Russell, Matthew R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hpbpb9bk8bke98genov07dnhss