AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells

AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells. Here we sought to determine the mechanism of action of AZD1775 in combination with chemotherapeutic agents in light of recent findings that A...

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Detalles Bibliográficos
Autores principales: Webster, Peter John, Littlejohns, Anna Tiffany, Gaunt, Hannah Jane, Prasad, K. Raj, Beech, David John, Burke, Dermot Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736347/
https://www.ncbi.nlm.nih.gov/pubmed/28296564
http://dx.doi.org/10.1080/15384101.2017.1301329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736347/
https://www.ncbi.nlm.nih.gov/pubmed/28296564
http://dx.doi.org/10.1080/15384101.2017.1301329

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