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End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8(+) T Cell Subsets
A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell-mediated immunity. Recently, we showed that ESRD...
| Автори: | , , , , , |
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| Формат: | Online Стаття Текст |
| Мова: | English |
| Опубліковано: |
Frontiers Media S.A.
2017
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| Предмети: | |
| Онлайн доступ: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736542/ https://www.ncbi.nlm.nih.gov/pubmed/29326709 http://dx.doi.org/10.3389/fimmu.2017.01826 |