End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8(+) T Cell Subsets

A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell-mediated immunity. Recently, we showed that ESRD...

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Bibliographic Details
Main Authors: Huang, Ling, Betjes, Michiel G. H., Klepper, Mariska, Langerak, Anton W., Baan, Carla C., Litjens, Nicolle H. R.
Format: Online Article Text
Language:English
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736542/
https://www.ncbi.nlm.nih.gov/pubmed/29326709
http://dx.doi.org/10.3389/fimmu.2017.01826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736542/
https://www.ncbi.nlm.nih.gov/pubmed/29326709
http://dx.doi.org/10.3389/fimmu.2017.01826

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