Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal cells. Through an unbiased CETSA screen, we identify the PIP4K lipid kinases as the target...

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Detalles Bibliográficos
Autores principales: Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Shang, See Cheng, Minami, Noriaki, Sampetrean, Oltea, Saya, Hideyuki, Lingyun, Dai, Prabhu, Nayana, Diam, Go Ka, Sobota, Radoslaw, Larsson, Andreas, Nordlund, Pär, McCormick, Frank, Ghosh, Sujoy, Epstein, David M., Dymock, Brian W., Lee, Sang Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736559/
https://www.ncbi.nlm.nih.gov/pubmed/29259156
http://dx.doi.org/10.1038/s41467-017-02287-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736559/
https://www.ncbi.nlm.nih.gov/pubmed/29259156
http://dx.doi.org/10.1038/s41467-017-02287-5

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