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Site-specific chromosomal gene insertion: Flp recombinase versus Cas9 nuclease
Site-specific recombination systems like those based on the Flp recombinase proved themselves as efficient tools for cell line engineering. The recent emergence of designer nucleases, especially RNA guided endonucleases like Cas9, has considerably broadened the available toolbox for applications lik...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736728/ https://www.ncbi.nlm.nih.gov/pubmed/29259215 http://dx.doi.org/10.1038/s41598-017-17651-0 |