A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture

PURPOSE: To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. METHOD: The permeability of seven compounds selected to possess a range of lipophilicity was measured in two airway cell l...

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Detalles Bibliográficos
Autores principales: Bosquillon, Cynthia, Madlova, Michaela, Patel, Nilesh, Clear, Nicola, Forbes, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736767/
https://www.ncbi.nlm.nih.gov/pubmed/28924829
http://dx.doi.org/10.1007/s11095-017-2251-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736767/
https://www.ncbi.nlm.nih.gov/pubmed/28924829
http://dx.doi.org/10.1007/s11095-017-2251-y

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