Pharmacokinetics of multiple doses of co‐crystal of tramadol–celecoxib: findings from a four‐way randomized open‐label phase I clinical trial

AIM: We compared the pharmacokinetic (PK) profiles of co‐crystal of tramadol–celecoxib (CTC) vs. each reference product (alone and in open combination) after single (first dose) and multiple dosing. METHODS: Healthy adults aged 18–50 years received, under fasted conditions, 15 twice‐daily doses of t...

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Detalles Bibliográficos
Autores principales: Videla, Sebastián, Lahjou, Mounia, Vaqué, Anna, Sust, Mariano, Escriche, Marisol, Soler, Lluis, Sans, Artur, Sicard, Eric, Gascón, Neus, Encina, Gregorio, Plata‐Salamán, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736845/
https://www.ncbi.nlm.nih.gov/pubmed/28888220
http://dx.doi.org/10.1111/bcp.13428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736845/
https://www.ncbi.nlm.nih.gov/pubmed/28888220
http://dx.doi.org/10.1111/bcp.13428

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