Xylopine Induces Oxidative Stress and Causes G(2)/M Phase Arrest, Triggering Caspase-Mediated Apoptosis by p53-Independent Pathway in HCT116 Cells

Xylopine is an aporphine alkaloid that has cytotoxic activity to cancer cells. In this study, the underlying mechanism of xylopine cytotoxicity was assessed in human colon carcinoma HCT116 cells. Xylopine displayed potent cytotoxicity in different cancer cell lines in monolayer cultures and in a 3D...

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Detalles Bibliográficos
Autores principales: Santos, Luciano de Souza, Silva, Valdenizia Rodrigues, Menezes, Leociley Rocha Alencar, Soares, Milena Botelho Pereira, Costa, Emmanoel Vilaça, Bezerra, Daniel Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736936/
https://www.ncbi.nlm.nih.gov/pubmed/29362667
http://dx.doi.org/10.1155/2017/7126872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736936/
https://www.ncbi.nlm.nih.gov/pubmed/29362667
http://dx.doi.org/10.1155/2017/7126872

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