Unraveling the Role of RNA Mediated Toxicity of C9orf72 Repeats in C9-FTD/ALS

The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is intronic hexanucleotide (G4C2) repeat expansions (HRE) in the C9orf72 gene. The non-exclusive pathogenic mechanisms by which C9orf72 repeat expansions contribute to these neurological disorder...

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Detalles Bibliográficos
Autores principales: Kumar, Vijay, Hasan, Gulam M., Hassan, Md. Imtaiyaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736982/
https://www.ncbi.nlm.nih.gov/pubmed/29326544
http://dx.doi.org/10.3389/fnins.2017.00711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736982/
https://www.ncbi.nlm.nih.gov/pubmed/29326544
http://dx.doi.org/10.3389/fnins.2017.00711

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