P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation

Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with elec...

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Detalles Bibliográficos
Autores principales: Latapiat, Verónica, Rodríguez, Felipe E., Godoy, Francisca, Montenegro, Felipe A., Barrera, Nelson P., Huidobro-Toro, Juan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737101/
https://www.ncbi.nlm.nih.gov/pubmed/29326590
http://dx.doi.org/10.3389/fphar.2017.00918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737101/
https://www.ncbi.nlm.nih.gov/pubmed/29326590
http://dx.doi.org/10.3389/fphar.2017.00918

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