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P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation

Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with elec...

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Detalles Bibliográficos
Autores principales:	Latapiat, Verónica, Rodríguez, Felipe E., Godoy, Francisca, Montenegro, Felipe A., Barrera, Nelson P., Huidobro-Toro, Juan P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737101/ https://www.ncbi.nlm.nih.gov/pubmed/29326590 http://dx.doi.org/10.3389/fphar.2017.00918

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