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Net Evolutionary Loss of Residue Polarity in Drosophilid Protein Cores Indicates Ongoing Optimization of Amino Acid Composition

Amino acid frequencies in proteins may not be at equilibrium. We consider two possible explanations for the nonzero net residue fluxes in drosophilid proteins. First, protein interiors may have a suboptimal residue composition and be under a selective pressure favoring stability, that is, leading to...

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Detalles Bibliográficos
Autores principales: Yampolsky, Lev Y., Wolf, Yuri I., Bouzinier, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737390/
https://www.ncbi.nlm.nih.gov/pubmed/28985302
http://dx.doi.org/10.1093/gbe/evx191