Specific reverse transcriptase slippage at the HIV ribosomal frameshift sequence: potential implications for modulation of GagPol synthesis

Synthesis of HIV GagPol involves a proportion of ribosomes translating a U6A shift site at the distal end of the gag gene performing a programmed -1 ribosomal frameshift event to enter the overlapping pol gene. In vitro studies here show that at the same shift motif HIV reverse transcriptase generat...

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Detalles Bibliográficos
Autores principales: Penno, Christophe, Kumari, Romika, Baranov, Pavel V., van Sinderen, Douwe, Atkins, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737442/
https://www.ncbi.nlm.nih.gov/pubmed/28973470
http://dx.doi.org/10.1093/nar/gkx690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737442/
https://www.ncbi.nlm.nih.gov/pubmed/28973470
http://dx.doi.org/10.1093/nar/gkx690

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