Activator Protein-1: redox switch controlling structure and DNA-binding

The transcription factor, activator protein-1 (AP-1), binds to cognate DNA under redox control; yet, the underlying mechanism has remained enigmatic. A series of crystal structures of the AP-1 FosB/JunD bZIP domains reveal ordered DNA-binding regions in both FosB and JunD even in absence DNA. Howeve...

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Detalles Bibliográficos
Autores principales: Yin, Zhou, Machius, Mischa, Nestler, Eric J., Rudenko, Gabby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737521/
https://www.ncbi.nlm.nih.gov/pubmed/28981703
http://dx.doi.org/10.1093/nar/gkx795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737521/
https://www.ncbi.nlm.nih.gov/pubmed/28981703
http://dx.doi.org/10.1093/nar/gkx795

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