Statistical algorithms improve accuracy of gene fusion detection

Gene fusions are known to play critical roles in tumor pathogenesis. Yet, sensitive and specific algorithms to detect gene fusions in cancer do not currently exist. In this paper, we present a new statistical algorithm, MACHETE (Mismatched Alignment CHimEra Tracking Engine), which achieves highly se...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsieh, Gillian, Bierman, Rob, Szabo, Linda, Lee, Alex Gia, Freeman, Donald E., Watson, Nathaniel, Sweet-Cordero, E. Alejandro, Salzman, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737606/
https://www.ncbi.nlm.nih.gov/pubmed/28541529
http://dx.doi.org/10.1093/nar/gkx453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737606/
https://www.ncbi.nlm.nih.gov/pubmed/28541529
http://dx.doi.org/10.1093/nar/gkx453

Ejemplares similares