BRD4 inhibitors block telomere elongation

Cancer cells maintain telomere length equilibrium to avoid senescence and apoptosis induced by short telomeres, which trigger the DNA damage response. Limiting the potential for telomere maintenance in cancer cells has been long been proposed as a therapeutic target. Using an unbiased shRNA screen t...

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Detalles Bibliográficos
Autores principales: Wang, Steven, Pike, Alexandra M., Lee, Stella S., Strong, Margaret A., Connelly, Carla J., Greider, Carol W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737673/
https://www.ncbi.nlm.nih.gov/pubmed/28854735
http://dx.doi.org/10.1093/nar/gkx561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737673/
https://www.ncbi.nlm.nih.gov/pubmed/28854735
http://dx.doi.org/10.1093/nar/gkx561

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