N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

N6-methyladenosine (m(6)A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m(6)A mRNA demethylase established the concept of reversible RNA modification. Here, we present a comprehensive transcriptome-wide analysis of RNA demethylation and un...

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Detalles Bibliográficos
Autores principales: Bartosovic, Marek, Molares, Helena Covelo, Gregorova, Pavlina, Hrossova, Dominika, Kudla, Grzegorz, Vanacova, Stepanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737695/
https://www.ncbi.nlm.nih.gov/pubmed/28977517
http://dx.doi.org/10.1093/nar/gkx778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737695/
https://www.ncbi.nlm.nih.gov/pubmed/28977517
http://dx.doi.org/10.1093/nar/gkx778

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