Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo

One of the fastest cellular responses to genotoxic stress is the formation of poly(ADP-ribose) polymers (PAR) by poly(ADP-ribose)polymerase 1 (PARP1, or ARTD1). PARP1 and its enzymatic product PAR regulate diverse biological processes, such as DNA repair, chromatin remodeling, transcription and cell...

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Detalles Bibliográficos
Autores principales: Schuhwerk, Harald, Bruhn, Christopher, Siniuk, Kanstantsin, Min, Wookee, Erener, Suheda, Grigaravicius, Paulius, Krüger, Annika, Ferrari, Elena, Zubel, Tabea, Lazaro, David, Monajembashi, Shamci, Kiesow, Kirstin, Kroll, Torsten, Bürkle, Alexander, Mangerich, Aswin, Hottiger, Michael, Wang, Zhao-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737718/
https://www.ncbi.nlm.nih.gov/pubmed/28977496
http://dx.doi.org/10.1093/nar/gkx717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737718/
https://www.ncbi.nlm.nih.gov/pubmed/28977496
http://dx.doi.org/10.1093/nar/gkx717

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