Quaternary interactions and supercoiling modulate the cooperative DNA binding of AGT

Human O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O(6)-alkylguanine and O(4)-alkylthymine adducts in single-stranded and duplex DNAs. The search for these lesions, through a vast excess of competing, unmodified genomic DNA, is a mechanistic challenge that may limit the repair rate...

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Detalles Bibliográficos
Autores principales: Melikishvili, Manana, Fried, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737729/
https://www.ncbi.nlm.nih.gov/pubmed/28575445
http://dx.doi.org/10.1093/nar/gkx223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737729/
https://www.ncbi.nlm.nih.gov/pubmed/28575445
http://dx.doi.org/10.1093/nar/gkx223

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