Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes

PURPOSE: Diabetes activates matrix metalloproteinase-9 (MMP-9), and MMP-9 via damaging retinal mitochondria, activates capillary cell apoptosis. MMP-9 promoter has binding sites for many transcription factors, and in diabetes its promoter undergoes epigenetic modifications, including histone modific...

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Detalles Bibliográficos
Autores principales: Duraisamy, Arul J., Mishra, Manish, Kowluru, Renu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737805/
https://www.ncbi.nlm.nih.gov/pubmed/29261844
http://dx.doi.org/10.1167/iovs.17-22706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737805/
https://www.ncbi.nlm.nih.gov/pubmed/29261844
http://dx.doi.org/10.1167/iovs.17-22706

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