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Inferring genetic interactions from comparative fitness data

Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population. Here, we present quantitative tools to make inferences about epistatic gene interactions when the fitness landscape is only incomp...

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Detalles Bibliográficos
Autores principales: Crona, Kristina, Gavryushkin, Alex, Greene, Devin, Beerenwinkel, Niko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737811/
https://www.ncbi.nlm.nih.gov/pubmed/29260711
http://dx.doi.org/10.7554/eLife.28629