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Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides
Antisense oligonucleotides (ASOs) are versatile tools that can regulate multiple steps of RNA biogenesis in cells and living organisms. Significant improvements in delivery, potency, and stability have been achieved through modifications within the oligonucleotide backbone, sugar and heterocycles. H...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737868/ https://www.ncbi.nlm.nih.gov/pubmed/28977508 http://dx.doi.org/10.1093/nar/gkx709 |