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Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides

Antisense oligonucleotides (ASOs) are versatile tools that can regulate multiple steps of RNA biogenesis in cells and living organisms. Significant improvements in delivery, potency, and stability have been achieved through modifications within the oligonucleotide backbone, sugar and heterocycles. H...

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Detalles Bibliográficos
Autores principales:	Bailey, Jeffrey K., Shen, Wen, Liang, Xue-hai, Crooke, Stanley T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737868/ https://www.ncbi.nlm.nih.gov/pubmed/28977508 http://dx.doi.org/10.1093/nar/gkx709

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