Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls the expression of extensive gene networks, driving both up- and down-regulation. GR utilizes multiple DNA-binding-dependent and -independent mechanisms to achieve context-specific transcriptional outcomes. The...

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Detalles Bibliográficos
Autores principales: Weikum, Emily R., de Vera, Ian Mitchelle S., Nwachukwu, Jerome C., Hudson, William H., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737878/
https://www.ncbi.nlm.nih.gov/pubmed/28591827
http://dx.doi.org/10.1093/nar/gkx509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737878/
https://www.ncbi.nlm.nih.gov/pubmed/28591827
http://dx.doi.org/10.1093/nar/gkx509

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