Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects

AIMS: FFA and FFA metabolites cause insulin resistance and impair beta cell function. The goal of our research was to examine whether elevation of plasma FFA impairs mitochondrial function and alters PGC-1α promoter methylation. METHODS: In this uncontrolled, change from baseline study design, insul...

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Detalles Bibliográficos
Autores principales: Eldor, Roy, Norton, Luke, Fourcaudot, Marcel, Galindo, Cynthia, DeFronzo, Ralph A., Abdul-Ghani, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737973/
https://www.ncbi.nlm.nih.gov/pubmed/29261667
http://dx.doi.org/10.1371/journal.pone.0188208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737973/
https://www.ncbi.nlm.nih.gov/pubmed/29261667
http://dx.doi.org/10.1371/journal.pone.0188208

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