Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

BACKGROUND: The 5′-methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and polyamine metabolism and in the methionine salvage pathway, is considered as a potential drug target against cancer and trypanosomiasis. In fact, Trypanosoma and Leishmania parasites lack de novo purine pat...

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Detalles Bibliográficos
Autores principales: Abid, Hela, Harigua-Souiai, Emna, Mejri, Thouraya, Barhoumi, Mourad, Guizani, Ikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738077/
https://www.ncbi.nlm.nih.gov/pubmed/29258562
http://dx.doi.org/10.1186/s12900-017-0079-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738077/
https://www.ncbi.nlm.nih.gov/pubmed/29258562
http://dx.doi.org/10.1186/s12900-017-0079-7

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