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Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

BACKGROUND: The 5′-methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and polyamine metabolism and in the methionine salvage pathway, is considered as a potential drug target against cancer and trypanosomiasis. In fact, Trypanosoma and Leishmania parasites lack de novo purine pat...

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Detalles Bibliográficos
Autores principales:	Abid, Hela, Harigua-Souiai, Emna, Mejri, Thouraya, Barhoumi, Mourad, Guizani, Ikram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738077/ https://www.ncbi.nlm.nih.gov/pubmed/29258562 http://dx.doi.org/10.1186/s12900-017-0079-7

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