Median regression spline modeling of longitudinal FEV(1) measurements in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients

RATIONALE: Clinical phenotyping, therapeutic investigations as well as genomic, airway secretion metabolomic and metagenomic investigations can benefit from robust, nonlinear modeling of FEV(1) in individual subjects. We demonstrate the utility of measuring FEV(1) dynamics in representative cystic f...

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Detalles Bibliográficos
Autores principales: Conrad, Douglas J., Bailey, Barbara A., Hardie, Jon A., Bakke, Per S., Eagan, Tomas M. L., Aarli, Bernt B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738083/
https://www.ncbi.nlm.nih.gov/pubmed/29261779
http://dx.doi.org/10.1371/journal.pone.0190061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738083/
https://www.ncbi.nlm.nih.gov/pubmed/29261779
http://dx.doi.org/10.1371/journal.pone.0190061

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