Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis

The epigenomic reader Brd4 is an important drug target for cancers. However, its role in cell differentiation and animal development remains largely unclear. Using two conditional knockout mouse strains and derived cells, we demonstrate that Brd4 controls cell identity gene induction and is essentia...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Eun, Park, Young-Kwon, Park, Sarah, Jang, Younghoon, Waring, Nicholas, Dey, Anup, Ozato, Keiko, Lai, Binbin, Peng, Weiqun, Ge, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738375/
https://www.ncbi.nlm.nih.gov/pubmed/29263365
http://dx.doi.org/10.1038/s41467-017-02403-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738375/
https://www.ncbi.nlm.nih.gov/pubmed/29263365
http://dx.doi.org/10.1038/s41467-017-02403-5

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