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Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
The epigenomic reader Brd4 is an important drug target for cancers. However, its role in cell differentiation and animal development remains largely unclear. Using two conditional knockout mouse strains and derived cells, we demonstrate that Brd4 controls cell identity gene induction and is essentia...
Autores principales: | Lee, Ji-Eun, Park, Young-Kwon, Park, Sarah, Jang, Younghoon, Waring, Nicholas, Dey, Anup, Ozato, Keiko, Lai, Binbin, Peng, Weiqun, Ge, Kai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738375/ https://www.ncbi.nlm.nih.gov/pubmed/29263365 http://dx.doi.org/10.1038/s41467-017-02403-5 |
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