Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3′-diindolylmethane. 3,3′-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and analysis showed the affinity of 3,3′-diindoly...

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Detalles Bibliográficos
Autores principales: Mahmud, Zobaer Al, Jenkins, Laura, Ulven, Trond, Labéguère, Frédéric, Gosmini, Romain, De Vos, Steve, Hudson, Brian D., Tikhonova, Irina G., Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738391/
https://www.ncbi.nlm.nih.gov/pubmed/29263400
http://dx.doi.org/10.1038/s41598-017-18159-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738391/
https://www.ncbi.nlm.nih.gov/pubmed/29263400
http://dx.doi.org/10.1038/s41598-017-18159-3

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