BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism

Clinical efficacy regularly requires the combination of drugs. For an early estimation of the clinical value of (potentially many) combinations of pharmacologic compounds during discovery, the observed combination effect is typically compared to that expected under a null model. Mechanistic accuracy...

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Detalles Bibliográficos
Autores principales: Van der Borght, Koen, Tourny, Annelies, Bagdziunas, Rytis, Thas, Olivier, Nazarov, Maxim, Turner, Heather, Verbist, Bie, Ceulemans, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738392/
https://www.ncbi.nlm.nih.gov/pubmed/29263342
http://dx.doi.org/10.1038/s41598-017-18068-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738392/
https://www.ncbi.nlm.nih.gov/pubmed/29263342
http://dx.doi.org/10.1038/s41598-017-18068-5

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