Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation

Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that function in pathways critical to cancer cell growth. Tankyrase-mediated PARylation marks protein targets for proteasomal degradation. Here, we generate human knockout cell lines to examine cell function and interrogate the proteome. We show tha...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Amit, Yang, Yanling, Ueberheide, Beatrix, Smith, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738441/
https://www.ncbi.nlm.nih.gov/pubmed/29263426
http://dx.doi.org/10.1038/s41467-017-02363-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738441/
https://www.ncbi.nlm.nih.gov/pubmed/29263426
http://dx.doi.org/10.1038/s41467-017-02363-w

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