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Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells
BACKGROUND: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738693/ https://www.ncbi.nlm.nih.gov/pubmed/29262834 http://dx.doi.org/10.1186/s12944-017-0641-0 |