Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

BACKGROUND: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in p...

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Detalles Bibliográficos
Autores principales: Gbelcová, Helena, Rimpelová, Silvie, Knejzlík, Zdeněk, Šáchová, Jana, Kolář, Michal, Strnad, Hynek, Repiská, Vanda, D’Acunto, Walter Cosimo, Ruml, Tomáš, Vítek, Libor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738693/
https://www.ncbi.nlm.nih.gov/pubmed/29262834
http://dx.doi.org/10.1186/s12944-017-0641-0

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