Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species

OBJECTIVE: The most common hereditary prion disease is human Creutzfeldt-Jakob disease (CJD), associated with a mutation in the prion gene resulting in a glutamic acid to lysine substitution at position 200 (E200K) in the prion protein. Models of E200K CJD in transgenic mice have proven interesting...

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Detalles Bibliográficos
Autores principales: Vrentas, Catherine E., Greenlee, Justin J., Foster, Gregory H., West, James, Jahnke, Marianna M., Schmidt, Mark T., Nicholson, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738711/
https://www.ncbi.nlm.nih.gov/pubmed/29262866
http://dx.doi.org/10.1186/s13104-017-3085-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738711/
https://www.ncbi.nlm.nih.gov/pubmed/29262866
http://dx.doi.org/10.1186/s13104-017-3085-8

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