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Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer’s Disease

BACKGROUND: Despite increased neuronal death, senile plaques, and neurofibrillary tangles observed in patients suffering from Alzheimer’s disease (AD), the detailed mechanism of cell death in AD is still poorly understood. METHOD: We hypothesized that p38 kinase activates and then phosphorylates Bax...

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Detalles Bibliográficos
Autores principales: Henderson, L.E., Abdelmegeed, M.A., Yoo, S.H., Rhee, S.G., Zhu, X., Smith, M.A., Nguyen, R.Q., Perry, G., Song, B.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738752/
https://www.ncbi.nlm.nih.gov/pubmed/29290835
http://dx.doi.org/10.2174/1874205X01711010048