Vps34 and the Armus/TBC-2 Rab GAPs: Putting the brakes on the endosomal Rab5 and Rab7 GTPases

Rab5 and Rab7 GTPases are key regulators of endosome maturation and lysosome fusion. They activate the class III phosphoinositide 3-kinase (PI3K) Vps34 to generate pools of phosphatidylinositol-3 phosphate [PI(3)P] on endosomes. Together PI(3)P and the GTP-bound Rabs coordinate the recruitment of en...

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Detalles Bibliográficos
Autores principales: Law, Fiona, Rocheleau, Christian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739090/
https://www.ncbi.nlm.nih.gov/pubmed/29296513
http://dx.doi.org/10.1080/21592799.2017.1403530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739090/
https://www.ncbi.nlm.nih.gov/pubmed/29296513
http://dx.doi.org/10.1080/21592799.2017.1403530

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