Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates

Recent avian and swine-origin influenza virus outbreaks illustrate the ongoing threat of influenza pandemics. We investigated immunogenicity and protective efficacy of a multi-antigen (MA) universal influenza DNA vaccine consisting of HA, M2, and NP antigens in cynomolgus macaques. Following challen...

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Detalles Bibliográficos
Autores principales: Koday, Merika T., Leonard, Jolie A., Munson, Paul, Forero, Adriana, Koday, Michael, Bratt, Debra L., Fuller, James T., Murnane, Robert, Qin, Shulin, Reinhart, Todd A., Duus, Karen, Messaoudi, Ilhem, Hartman, Amy L., Stefano-Cole, Kelly, Morrison, Juliet, Katze, Michael G., Fuller, Deborah Heydenburg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739435/
https://www.ncbi.nlm.nih.gov/pubmed/29267331
http://dx.doi.org/10.1371/journal.pone.0189780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739435/
https://www.ncbi.nlm.nih.gov/pubmed/29267331
http://dx.doi.org/10.1371/journal.pone.0189780

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