A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in oncogenesis remains poorly understood. Here we re...

Descripción completa

Detalles Bibliográficos
Autores principales: Woods, Elliot C, Kai, FuiBoon, Barnes, J Matthew, Pedram, Kayvon, Pickup, Michael W, Hollander, Michael J, Weaver, Valerie M, Bertozzi, Carolyn R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739539/
https://www.ncbi.nlm.nih.gov/pubmed/29266001
http://dx.doi.org/10.7554/eLife.25752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739539/
https://www.ncbi.nlm.nih.gov/pubmed/29266001
http://dx.doi.org/10.7554/eLife.25752

Ejemplares similares