Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs) suppress activation/proliferation of cytotoxic T cells, thereby hindering cancer immunotherapy. MDSCs are increased after adjuvant therapy with toll-like receptor (TLR) 2 ligands, such as Pam2CSK4, in tumor-bearing mice. However, it remains unk...

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Detalles Bibliográficos
Autores principales: Shime, Hiroaki, Maruyama, Akira, Yoshida, Sumito, Takeda, Yohei, Matsumoto, Misako, Seya, Tsukasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739553/
https://www.ncbi.nlm.nih.gov/pubmed/29296526
http://dx.doi.org/10.1080/2162402X.2017.1373231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739553/
https://www.ncbi.nlm.nih.gov/pubmed/29296526
http://dx.doi.org/10.1080/2162402X.2017.1373231

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