MicroRNA-200a activates Nrf2 signaling to protect osteoblasts from dexamethasone

Treatment with dexamethasone in human osteoblasts leads to oxidative stress and cell injures. NF-E2-related factor 2 (Nrf2) is a key anti-oxidant signaling. We want to induce Nrf2 activation via microRNA-mediated silencing its suppressor Keap1. Our results show that microRNA-200a (“miR-200a”) expres...

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Detalles Bibliográficos
Autores principales: Zhao, Sai, Mao, Li, Wang, Shou-Guo, Chen, Feng-Li, Ji, Feng, Fei, Hao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739606/
https://www.ncbi.nlm.nih.gov/pubmed/29285219
http://dx.doi.org/10.18632/oncotarget.20452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739606/
https://www.ncbi.nlm.nih.gov/pubmed/29285219
http://dx.doi.org/10.18632/oncotarget.20452

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