Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7

Anthrapyridazones, imino analogues of anthraquinone, constitute a family of compounds with remarkable anti-cancer activity. To date, over 20 derivatives were studied, of which most displayed nanomolar cytotoxicity towards broad spectrum of cancer cells, including breast, prostate and leukemic ones....

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Detalles Bibliográficos
Autores principales: Misiak, Majus, Heldt, Mateusz, Szeligowska, Marlena, Mazzini, Stefania, Scaglioni, Leonardo, Grabe, Grzegorz J., Serocki, Marcin, Lica, Jan, Switalska, Marta, Wietrzyk, Joanna, Beretta, Giovanni L., Perego, Paola, Zietkowski, Dominik, Baginski, Maciej, Borowski, Edward, Skladanowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739627/
https://www.ncbi.nlm.nih.gov/pubmed/29285240
http://dx.doi.org/10.18632/oncotarget.21806

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