Abnormally glycosylated MUC1 establishes a positive feedback circuit of inflammatory cytokines, mediated by NF-κB p65 and EzH2, in colitis-associated cancer

The abnormal hypoglycosylated form of the epithelial mucin MUC1 is over-expressed in chronic inflammation and on human adenocarcinomas, suggesting its potential role in inflammation-driven tumorigenesis. The presence of human MUC1 aggravates colonic inflammation and increases tumor initiation and pr...

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Detalles Bibliográficos
Autores principales: Cascio, Sandra, Faylo, Jacque L., Sciurba, Joshua C., Xue, Jia, Ranganathan, Sarangarajan, Lohmueller, Jason J., Beatty, Pamela L., Finn, Olivera J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739638/
https://www.ncbi.nlm.nih.gov/pubmed/29285251
http://dx.doi.org/10.18632/oncotarget.22168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739638/
https://www.ncbi.nlm.nih.gov/pubmed/29285251
http://dx.doi.org/10.18632/oncotarget.22168

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