Cargando…

Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo

Evaluating the process and mechanism of fibrogenesis is essential in hepatocellular carcinoma (HCC), especially in hepatocyte transformation and oncogenic signaling. We evaluated the oncogenic role of agrin secreted by platelet-derived growth factor (PDGF)-induced hepatic stellate cell (HSC) in HCC....

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Xing, Fang, Cheng, Yin, Ruozhe, Qiao, Bowei, Shang, Runze, Wang, Jianlin, Song, Wenjie, He, Yong, Chen, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739642/ https://www.ncbi.nlm.nih.gov/pubmed/29285255 http://dx.doi.org/10.18632/oncotarget.22186

Ejemplares similares

Hepatic Stellate Cells and Hepatocarcinogenesis
por: Barry, Anna E., et al.
Publicado: (2020)

Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling
por: Nakamura, Ikuo, et al.
Publicado: (2014)

Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling
por: Nakamura, Ikuo, et al.
Publicado: (2015)

Agrin drives synaptogenesis
por: Tuma, Rabiya S.
Publicado: (2005)

Agrin at CNS synapses
por: Dove, Alan W.
Publicado: (2003)

β-PDGF Receptor Expressed by Hepatic Stellate Cells Regulates Fibrosis in Murine Liver Injury, but Not Carcinogenesis
por: Kocabayoglu, Peri, et al.
Publicado: (2015)

Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons
por: Jacquier, Arnaud, et al.
Publicado: (2022)

Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells
por: Wang, Xingqi, et al.
Publicado: (2020)

An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix
Publicado: (1995)

MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion
por: O’Connor, Emily, et al.
Publicado: (2018)

Oncogene-dependent function of BRG1 in hepatocarcinogenesis
por: Wang, Pan, et al.
Publicado: (2020)

Effects of Purified Recombinant Neural and Muscle Agrin on Skeletal Muscle Fibers in Vivo
por: Bezakova, Gabriela, et al.
Publicado: (2001)

Autoantibodies to Agrin in Myasthenia Gravis Patients
por: Zhang, Bin, et al.
Publicado: (2014)

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB
por: Gao, Si-yong, et al.
Publicado: (2017)

PDGF and PDGF receptors in glioma
por: Nazarenko, Inga, et al.
Publicado: (2012)

Novel LG1 Mutations in Agrin Causing Congenital Myasthenia Syndrome
por: Xia, Ping, et al.
Publicado: (2021)

Shaping Membrane Architecture: Agrins in and Out of the Synapse
por: Hagiwara, Hiroki, et al.
Publicado: (2001)

Motor neurons contain agrin-like molecules
Publicado: (1988)

Endothelial Agrin Is Dispensable for Normal and Tumor Angiogenesis
por: Ye, Peng, et al.
Publicado: (2022)

Hepatitis C virus and hepatocarcinogenesis
por: Jeong, Soung Won, et al.
Publicado: (2012)

Agrin Influences Botulinum Neurotoxin A-Induced Nerve Sprouting via miR-144-agrin-MuSK Signaling
por: Ma, Lin, et al.
Publicado: (2020)

Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis
por: Yang, Yang, et al.
Publicado: (2021)

Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration
por: Pratt, Jedd, et al.
Publicado: (2023)

Proteomic analysis of human umbilical cord serum exosomes using mass spectrometry and preliminary study of their biological activities in liver cancer cell lines
por: Zhu, Donglie, et al.
Publicado: (2022)

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism
por: Wilhelm, Annika, et al.
Publicado: (2016)

Astragaloside IV regulates NF-κB-mediated cellular senescence and apoptosis of hepatic stellate cells to suppress PDGF-BB-induced activation
por: Chen, Zhiwei, et al.
Publicado: (2019)

Agrin plays an organizing role in the formation of sympathetic synapses
por: Gingras, Jacinthe, et al.
Publicado: (2002)

Agrin-Mediated Cardiac Regeneration: Some Open Questions
por: Bigotti, Maria Giulia, et al.
Publicado: (2020)

Agrin is a novel oncogenic protein in thyroid cancer
por: Adamiok-Ostrowska, Anna, et al.
Publicado: (2023)

Antibodies to Full-Length Agrin Protein in Chinese Patients With Myasthenia Gravis
por: Wang, Shumin, et al.
Publicado: (2021)

Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis
por: Kim, Byeong-Moo, et al.
Publicado: (2018)

Novel SEA and LG2 Agrin mutations causing congenital Myasthenic syndrome
por: Xi, Jianying, et al.
Publicado: (2017)

Pigment Epithelium-Derived Factor 34-mer Peptide Prevents Liver Fibrosis and Hepatic Stellate Cell Activation through Down-Regulation of the PDGF Receptor
por: Tsai, Tung-Han, et al.
Publicado: (2014)

Alcohol and hepatocarcinogenesis
por: Taniai, Makiko
Publicado: (2020)

Enzymic retrodifferentiation during hepatocarcinogenesis and liver regeneration in rats in vivo.
por: Curtin, N. J., et al.
Publicado: (1983)

Low plasma PDGF-BB levels are associated with estradiol in postmenopausal osteoporosis: PDGF-BB mediated by estradiol in women
por: Tang, Lanhua, et al.
Publicado: (2017)

Agrin-induced clustering of acetylcholine receptors: a cytoskeletal link
Publicado: (1994)

Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation
Publicado: (1994)

Agrin Binds to the Nerve–Muscle Basal Lamina via Laminin
por: Denzer, Alain J., et al.
Publicado: (1997)

Site Specific Cleavage Mediated by MMPs Regulates Function of Agrin
por: Patel, Trushar R., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_otnku2lbqv69c1msadgenk8914