Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Loss-of-function mutations in PINK1 or PARKIN are associated with early-onset Parkinson’s disease. Upon mitochondrial stress, PINK1 and Parkin together mediate a response that protects cells from the accumulation of harmful, damaged mitochondria. PINK1, the upstream kinase accumulates on the mitocho...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiesel, Fabienne C., James, Elle D., Hudec, Roman, Springer, Wolfdieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739729/
https://www.ncbi.nlm.nih.gov/pubmed/29290944
http://dx.doi.org/10.18632/oncotarget.22287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739729/
https://www.ncbi.nlm.nih.gov/pubmed/29290944
http://dx.doi.org/10.18632/oncotarget.22287

Ejemplares similares