WEE1 epigenetically modulates 5-hmC levels by pY37-H2B dependent regulation of IDH2 gene expression

Epigenetic signaling networks dynamically regulate gene expression to maintain cellular homeostasis. Previously, we uncovered that WEE1 phosphorylates histone H2B at tyrosine 37 (pY37-H2B) to negatively regulate global histone transcriptional output. Although pY37-H2B is readily detected in cancer c...

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Detalles Bibliográficos
Autores principales: Mahajan, Nupam P., Malla, Pavani, Bhagwat, Shambhavi, Sharma, Vasundhara, Sarnaik, Amod, Kim, Jongphil, Pilon-Thomas, Shari, Weber, Jeffery, Mahajan, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739739/
https://www.ncbi.nlm.nih.gov/pubmed/29290954
http://dx.doi.org/10.18632/oncotarget.22374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739739/
https://www.ncbi.nlm.nih.gov/pubmed/29290954
http://dx.doi.org/10.18632/oncotarget.22374

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