BTK blocks the inhibitory effects of MDM2 on p53 activity

p53 is a tumour suppressor that is activated in response to various types of stress. It is regulated by a complex pattern of over 50 different post-translational modifications, including ubiquitination by the E3 ligase MDM2, which leads to its proteasomal degradation. We have previously reported tha...

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Detalles Bibliográficos
Autores principales: Rada, Miran, Althubiti, Mohammad, Ekpenyong-Akiba, Akang E., Lee, Koon-Guan, Lam, Kong Peng, Fedorova, Olga, Barlev, Nickolai A., Macip, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739762/
https://www.ncbi.nlm.nih.gov/pubmed/29290977
http://dx.doi.org/10.18632/oncotarget.22543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739762/
https://www.ncbi.nlm.nih.gov/pubmed/29290977
http://dx.doi.org/10.18632/oncotarget.22543

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