Mutations in the DNA methylation pathway and number of driver mutations predict response to azacitidine in myelodysplastic syndromes

We evaluated the association of mutations in 34 candidate genes and response to azacitidine in 84 patients with myelodysplastic syndrome (MDS), with 217 somatic mutations identified by next-generation sequencing. Most patients (93%) had ≥1 mutation (mean=2.6/patient). The overall response rate to az...

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Detalles Bibliográficos
Autores principales: Cedena, M. Teresa, Rapado, Inmaculada, Santos-Lozano, Alejandro, Ayala, Rosa, Onecha, Esther, Abaigar, María, Such, Esperanza, Ramos, Fernando, Cervera, José, Díez-Campelo, María, Sanz, Guillermo, Rivas, Jesús Hernández, Lucía, Alejandro, Martínez-López, Joaquin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739787/
https://www.ncbi.nlm.nih.gov/pubmed/29291002
http://dx.doi.org/10.18632/oncotarget.22157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739787/
https://www.ncbi.nlm.nih.gov/pubmed/29291002
http://dx.doi.org/10.18632/oncotarget.22157

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